Epigenetic regulation of the genome
About the CourseThe “Epigenetics” term refers to the alterations of gene expression and activity beyond the sequence of DNA, where epigenetic mechanisms, such as DNA methylation, histone modifications and the transmission of non-DNA molecules like RNA, are inherited and interpreted by proteins that facilitate downstream biological effects. The course will explore the molecular mechanisms at the basis of epigenetic phenomena, among which the histone code, genetic imprinting and dosage compensation. Finally, the importance of Epigenetics in human diseases will be discussed.
After the completion of the course, the students will be able to:
- describe the epigenetic regulation and its role in human health;
- outline the most modern and relevant molecular biology techniques useful for the study of epigenetic regulation;
- interpret and comment the most recent discoveries in the field of epigenetics.
Background and RequirementsThe course is aimed at all those who have good knowledge of genetics and molecular biology.
TextbooksThe selected scientific publications are indicated in the course pages.
Course FormatThe course is divided into five sections that address the following topics: the principles of epigenetics - the chromatin assembly and the inheritance of the chromatin state; the protein complexes involved in histone post-translational modifications and chromatin remodeling; the chromatin role and remodeling in the control of gene transcription; the molecular processes underlying genomic imprinting; the molecular processes underlying dosage compensation; epigenetics in cellular transformation; the main techniques used in the study of chromatin.
Certificates and Exam rules
In order to obtain the certificate of participation and the open badge, it is necessary to pass the final evaluation questionnaire after having viewed all the video lessons, including those that will be held in streaming during the period between the 1st and 31st of May (the registration and publication of the latter is foreseen for those who will not be able to participate in these events synchronously). More complete information on streaming lessons will be made available at the beginning of the course.